Pfizer-BioNTech Vaccine Called for Powerful Safety in Adolescents

The Pfizer-BioNotech Coronavirus Vaccine is extremely effective in young teens, perhaps even more than in adults, the companies reported Wednesday – a discovery that could make a return to normalcy easier for millions of American families.

Drug manufacturers said that no infectious infection has been found in children between the ages of 12 and 15 who received the vaccine in a recent clinical trial; Children produced strong antibody reactions and experienced no serious side effects.

Depending on regulatory approval, vaccination may begin before the start of the next academic year for middle school and high school students, and not later than for primary school children.

The companies announced the results in a statement that did not include detailed data from the test, which has not yet been reviewed nor published in a scientific journal. Nevertheless, the news attracted praise and enthusiasm from experts.

“Oh my God, I’m so happy to see that – it’s amazing,” said Akiko Iwasaki, an immunologist at Yale University. If the performance of vaccines was A-plus in adults, the results in children were “A-plus-plus”.

The good news also comes as the country registers another increase in infections and health officials make fresh calls for caution and vaccination for Americans. On Monday, the director of the Centers for Disease Control and Prevention, Drs. Rochelle Wallensky said that increasing cases Had left him with a sense of “impending doom” While President Biden called on state and local officials to reinstate the masked mandate.

Vaccination efforts are gaining momentum across the nation. As of Tuesday, 29 percent of Americans At least one dose of the coronavirus vaccine was obtained, And 16 percent was completely deactivated, according to the CDC

But the country cannot hope to reach herd immunity – at which point immunity becomes so widespread that it slows its crawl through the coronovirus population – without vaccinating the youngest Americans, some experts say is. About 23 percent of the population in the United States has children under 18.

“The sooner we can get vaccinated to the same number of people, regardless of our age, the sooner we can truly feel that we are ending this epidemic for good,” said Engra Rasmussen, a Georgetown University affiliate The biologist said. In Washington.

Israel’s data suggest that vaccinating adults alone can significantly reduce the number of cases, but “to kill the long-term immune herd, we have to vaccinate children,” he said.

The trial consisted of 2,260 adolescents ages 12 to 15. Children received two doses of the vaccine three weeks apart – the same amount and schedule used for adults – or a place of saltwater.

Researchers reported 18 cases of symptomatic coronovirus infection in the placebo group, and none of the children who received the vaccine. Dr. Rasmuss said the still low number of infections makes it difficult to be very specific about the effectiveness of the vaccine in the population.

“But obviously, it sounds good for the vaccine if there were zero Kovid cases among the vaccinated people,” she said.

Adolescents who received the vaccine produced, on average, a much higher level of antibodies than participants aged 16 to 25 per trial. Children experienced the same minor side effects as older participants, although the companies refused to be more specific.

Dr. Iwasaki stated that he expected antibody levels in adolescents to be comparable to those in young adults. “But they are getting even better levels from vaccines,” she said. “It’s really incredible.”

She and other experts cautioned that the vaccine may be less effective in children and adults, against some variants that have begun to roam the United States.

Pfizer and Bayonet have begun clinical trials and vaccination in children under 12 years of age. Children ages 5 to 11 Just last week. Scientists at the company plan to introduce the vaccination next week, even in young children, ages 2 to 5, followed by testing in children between 6 months to 2 years old.

Results of a three-phase test are expected in the second half of that year, and companies are expected to make the vaccine available to children under 12 by early next year.

Pfizer President and Chief Executive Officer Albert Borla said in a statement, “We encourage the use of our vaccine to expand to additional populations, and for clinical trial data from adolescents between the ages of 12 and 15 . “

Modernity has also been Its vaccine test Among children. The results of a test in adolescents between 12 and 17 years of age are expected in the next few weeks and in children 6 months to 12 years old in the second half of this year.

AstraZeneca has begun testing its vaccines in children 6 months and up to the last month, and Johnson & Johnson has said that it will test results in older children before testing its vaccine in children under 12 years of age. Will wait

Some parents have stated that they are reluctant to vaccinate their children because the risk posed by the virus is low. Children die from Kovid-19 less than 1 percent, but about 2 percent of children with the disease require hospital care.

Jennifer Nuzzo, an epidemiologist at the Johns Hopkins Center for Health Security, said the new results may not be for all parents, but they can reassure parents who have been wary of vaccines.

He said, “I don’t think we have to wait until the children are vaccinated to fully open the school, being able to vaccinate the children makes some families feel safe returning to school.” Can help, ”she said.

Pfizer and BioNotech plan to request the Food and Drug Administration to amend the Emergency Use Authority for their vaccines, in hopes of vaccinating older children before the start of the next school year. The companies also plan to submit their data for peer review and publication in a scientific journal.

They will monitor participants for two years after the second dose to assess the long-term safety and efficacy of the vaccine. Vaccine side effects are usually evident within the first six weeks, with pediatrician and vaccine specialist Dr. Mt. Sinai Hospital in New York. Kristin Oliver said. “Nevertheless, it is good to know that security surveillance continues,” she said.

The CDC recommends that people refrain from taking other vaccines for two weeks before and after receiving two doses of the coronovirus vaccine.

Dr. Oliver said that children get more vaccines in the first few weeks before the school year, so pediatricians and parents should aim to do those other vaccinations earlier than normal.

Dr. Oliver said that the coronovirus vaccine should ideally be given by pediatricians who have deep experience in vaccination for children. “Now it’s time to start planning how the rollout is going to be in this age group,” she said.

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